Leon Aarons

[email protected]
Leon Aarons is a Professor in the School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK. His research interest are in population and physiologically based pharmacokinetics.

Nick Holford


[email protected]
Nick Holford is Professor of Clinical Pharmacology at the University of Auckland, Auckland, New Zealand.  His main interests are PK and PKPD modelling.  He has particular interests in describing disease progression, influence of drug treatments on disease and dosing of children.

Steve Duffull

MPharm, PhD, FNZCP

[email protected]
Stephen Duffull is Professor of Clinical Pharmacy at the University of Otago, Dunedin, New Zealand. He runs the Otago Pharmacometrics Group within the School of Pharmacy. Research interests include quantitative systems pharmacology, optimal design, MCMC methods particularly in clinical toxicology and haemostasis. He has been involved in the area of PKPD and nonlinear mixed effects modelling for 20 years.

Mats Karlsson


[email protected]
Mats O. Karlsson is professor of pharmacometrics at Uppsala University, Sweden where he leads a multi-disciplinary research group of more than 30 scientists. His research interests focus on methodological aspects of non-linear mixed effects model building and applications of PKPD modelling in drug development and drug usage.

France Mentré


[email protected]
France Mentré is Professor of Biostatistics at the University  Paris Diderot (Paris 7), France.  She heads an INSERM research team on Biostatistical Modelling and Pharmacometrics.  She has worked on development and application of methods for nonlinear mixed-effects models in pharmacokinetics and pharmacodynamics for more than 20 years. Her main research areas in this field are optimal design, model evaluation and anti-infective agents.