The Sheiner-Rowland Advanced Course in PKPD Melbourne 2018

Sunday 28 January through Friday 2 February

An advanced course presenting aspects and applications of pharmacokinetics, pharmacodynamics and kinetic/dynamic data analysis in the medical and pharmaceutical sciences.

For whom intended:
The Course is designed for those who have a good working knowledge of basic concepts in pharmacokinetics, pharmacodynamics and data analysis and who now wish to extend their knowledge further. Emphasis will be placed on relating pharmacokinetics to underlying physiological processes and to pharmacodynamics, and on the analysis and modelling of pharmacokinetic and pharmacodynamic data.

Course content: 
The mornings will be devoted to lectures; the late afternoons to small-group workshops led by experienced tutors, in which participants will solve practical problems and develop facility with the techniques and approaches discussed in the lectures. The participants are encouraged to raise questions from their experience for discussion: time is specifically reserved for informal consultations.

Course manual: 
A course manual, comprising lecture outlines, derivations, problem sets with answers, and additional reading material will be provided in an electronic format.

This is not a computer modelling training course. There are no computer exercises. However, participants should come with a scientific hand calculator or notebook computer.

Ability to understand and converse in English is essential.

Timetable: (provisional)

Monday 29th January

 08:45-09:00                 Introduction (Leon Aarons)

09:00-10:15                 Lecture 1 – Empirical Pharmacokinetics (Leon Aarons)

10:15-10:45                 Coffee & Tea

10:45-12:00                 Lecture 2 – Pharmacodynamic Principles (Steve Duffull)

12:30-14:00                 Lunch

14:00-17:00                 Workshop I – Empirical PKPD Principles

17:00-18:00                 Consultation (optional) Mats Karlsson/Nick Holford

 18:00                           Welcome reception (location to be announced)


Tuesday 30th January

09:00-10:15                 Lecture 3 – Physiologically Based Pharmacokinetics (Leon Aarons)

10:15-10:45                 Coffee

10:45-12:00                 Lecture 4 – PKPD Principles (Nick Holford)

12:30-14:00                 Lunch

14:00-17:00                 Workshop II – PBPK and PKPD Principles

17:00-18:00                 Consultation (optional) Steve Duffull/Leon Aarons


Wednesday 31st January

09:00-10:15                 Lecture 5 – Nonlinear regression (Leon Aarons)

10:15-10:45                 Coffee

10:45-12:00                 Lecture 6 – Population PKPD – Models and methods (Mats Karlsson)

12:30-14:00                 Lunch

14:00-17:00                 Workshop III – Nonlinear regression/Population PK

17:00-18:00                 Consultation (optional) Mats Karlsson/Nick Holford


Thursday 1st February

 09:00-10:15                 Lecture 7 – Population PKPD – Modelling (Mats Karlsson)

10:15-10:45                 Coffee

10:45-12:00                 Lecture 8 – Disease Progression Principles (Nick Holford)

12:30-14:00                 Lunch

14:00-17:00                 Workshop IV – Population PKPD and Disease Progression Principles

17:00-18:00                 Consultation (optional) Leon Aarons/Steve Duffull

 19:30                          Course Dinner (location to be announced)


Friday 2nd February

 09:00-10:15                 Lecture 9 – Optimal design (Steve Duffull)

10:15-10:45                 Coffee

10:45-12:00                Lecture 10 – Models for discrete and time-to-event data (Mats Karlsson)

12:00                           Lunch



Course fee: 

Academic and Regulatory Institutions: AUD2400

Other institutions: AUD3600

The fee includes breakfast, lunch, coffee breaks, opening reception, and one evening dinner. Enrollment is limited to 50, so prospective participants are encouraged to register in advance. Early bird registration is available at a discounted fee. A limited number of spaces at a reduced fee are available to academic and government persons.

A limited number of places will be available for participants from low-middle income countries with a 50% reduced fee. Participants may enquire to Prof Stephen Duffull <[email protected]>



Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Melbourne, Victoria, Australia.

Please note, this meeting will be held at the Parkville campus, Monash University, not the Clayton Campus (which is 25 km away).


Recommended accommodation for the conference includes:

Vibe Hotel Carlton (2 mins walk)

Parkville Place Apartments (5-10 mins walk through park)

There are serviced apartment options in Elizabeth Street, which is on the #19 tram route to the Parkville campus from the city or on Lygon St  which is a short walk (10-20 mins) away.

Administrative contact: Carl Kirkpatrick <[email protected]>

Following this Course, the Population Approach Group of Australia and New Zealand workshop ( will be held in the same location from 5th to 7th February.  This will require a separate registration and fee.