A Workshop, presenting advanced aspects and applications of pharmacokinetics, pharmacodynamics and kinetic/dynamic data analysis in the medical and pharmaceutical sciences.
For whom intended:
The Workshop is designed for those who have a good working knowledge of basic concepts in pharmacokinetics, pharmacodynamics and data analysis and who now wish to extend their knowledge further. Emphasis will be placed on relating pharmacokinetics to underlying physiological processes and to pharmacodynamics, and on the analysis and modelling of pharmacokinetic and pharmacodynamic data.
Workshop content:
The mornings will be devoted to lectures; the afternoons to small-group workshops led by experienced tutors, in which participants will solve practical problems and develop facility with the techniques and approaches discussed in the lectures. The participants are encouraged to raise questions from their experience for discussion: time is specifically reserved for such informal discussions.
Workshop manual:
A course manual, comprising lecture outlines, derivations, problem sets with answers, and additional reading material will be provided in an electronic format. Participants should come with a scientific hand calculator.
Topics to be covered include:
Empirical models for pharmacokinetics and pharmacodynamics
Mechanistic models for pharmacokinetics (compartmental, physiological) and pharmacodynamics (receptor theory) and combined PKPD (immediate and delayed effects)
Data analysis techniques for empirical or mechanistic modeling: point estimates, confidence intervals, hypothesis tests.
Population pharmacokinetics and pharmacodynamics.
Disease progress and drug action modeling
Optimal design
TYPICAL WORKSHOP TIMETABLE
Sunday
18.00-20.00 Registration and Welcome Reception
Monday
8.45-9.00 Introduction to Workshop
9.00-10.15 Lecture 1 - Empirical Pharmacokinetics
10.15-10.45 Coffee
10.45-12.00 Lecture 2 – Physiologically Based Pharmacokinetics
12.30-14.00 Lunch
15.00-16.00 Consultation (optional)
16.00-19.00 Workshop I - Empirical/mechanistic pharmacokinetics
Tuesday 14th February
9.00-10.15 Lecture 3 – Pharmacodynamic Principles
10.15-10.45 Coffee
10.45-12.00 Lecture 4 – PKPD principles
12.30-14.00 Lunch
* Workshop II – Pharmacodynamics and PKPD
* Consultation (optional)
Wednesday
9.00-10.15 Lecture 5 – Nonlinear regression
10.15-10.45 Coffee
10.45-12.00 Lecture 6 – Population PKPD 1
12.30-14.00 Lunch
* Workshop III – Nonlinear regression/Population PK
* Consultation (optional)
Thursday
9.00-10.15 Lecture 7 – Population PKPD 2
10.15-19.45 Coffee
10.45-12.00 Lecture 8 – Disease Progression Principles
12.30-14.00 Lunch
* Workshop IV – Population PKPD/Disease progression
* Consultation (optional)
Friday
9.00-10.15 Lecture 9 – Optimal design
10.45-12.00 Lecture 10 – Models for discrete and time-to-event data
* Workshop and consultation times vary
END OF WORKSHOP